Free-spirited con Randle P. McMurphy (Jack Nicholson) fakes insanity and moves into the state mental hospital with what he calls the "nuts." Immediately, his contagious sense of disorder runs up against numbing routine. This means war! On one side is McMurphy. On the other soft-spoken Nurse Ratched (Louise Fletcher), among the most coldly monstrous villains in film history. At stake is the fate of every patient on the ward.

An elite team of medical and scientific specialists race to save a top government scientist who is suffering from blood clot on the brain. Their mission is to be reduced along with their submarine-like craft to microscope size, enter the bloodstream of the ailing scientist, and journey to the brain to perform an emergency procedure. With only sixty minutes to complete their mission, the scientists find themselves fighting off an attack by white corpuscles,...